Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8, HHV8), is a gamma herpesvirus that contain an open reading frame encoding a G protein-coupled receptor (GPCR) with putative 7 transmembrane domains. This GPCR has been shown to bind a number of chemokines including IL8, NAP2, PF4, MGSA/Gro alpha, I309, RANTES, MCP1, and MIP1 beta. The receptor is constitutively activated without chemokine binding, and it stimulates cell proliferation. KSHV GPCR is also a viral oncogene that stimulates angio-genesis through induction of VEGF expression. IP10, a chemokine, can inhibit constitutively activated KSHV GPCR.